This approach allows assessment of age-specific PSA levels. For men younger than 50 years of age, PSA levels should be 0-2.5 ng/mL. For men 50-59 years of age, normal PSA levels are 0-3.5 ng/mL. For men 60-69 years of age, PSA should be 0-4.5 ng/mL. Guidelines for PSA screening exist for the following age groups: Age 55 and younger: People at high risk for prostate cancer, including those with a biological family history of prostate cancer and Black men. Age 55 to 69: Screening for people at average risk for prostate cancer. Over 70: Healthcare providers don't recommend screening. Some cancer cells do not produce much PSA, so it is possible to have a normal result yet have cancer. Recent studies have shown that there is still a small risk of prostate cancer, even if blood PSA levels are normal for age. PSA levels can vary, so your doctor may decide to repeat the test to compare your results over time. The age-specific PSA reference ranges are as follows: 40-49 years, 2.15 ng mL −1; 50-59 years, 3.20 ng mL −1; 60-69 years, 4.10 ng mL −1; 70-79 years, 5.37 ng mL −1. The results indicate that the ethnic differences in PSA levels are obvious. The currently adopted Oesterling's age-specific PSA reference ranges are not appropriate Some experts use age-specific reference ranges for PSA, rather than using the same cutoff for all ages. PSA levels generally increase with age, in part because older males are more likely to have a benign enlarged prostate producing larger amounts of PSA. Among males with a normal PSA level, abnormalities on DRE appeared less likely to be The results of the prostate-specific antigen test are reported as nanograms of prostate specific antigens per millimeter of blood. Earlier, 4.0 ng/ml or below was considered the PSA test normal range. However, studies show you can have prostate cancer with prostate-specific antigen levels below 4.0 ng/ml. March 1, 2012. The prostate-specific antigen (PSA) test is the most important issue in men's health. That's because prostate cancer is the most common internal malignancy in American men, and the great majority of the 240,000 new cases expected this year will be diagnosed because of the PSA test. The PSA is also the most controversial issue in The prostate-specific antigen (PSA) test can detect prostate cancer early enough for treatment, but it cannot determine whether the cancer is aggressive or indolent, and overdiagnosis is its biggest drawback. Age group. Proposed normal PSA range. 40 - 49 0 -2.5 ng/mL 50 - 59 0 - 3.5 ng/mL 60 - 69 0 - 4.5 ng/mL 70 -79 0 - 6.5 Prostate cancer is the most frequently diagnosed cancer in 112 countries and the leading cause of cancer death in 48 countries.[1] It is the fifth leading cause of male cancer-related deaths worldwide, with more than 1.4 million newly diagnosed cases and 375,304 deaths reported annually.[2] Prostate-specific antigen (PSA) is a protein produced by cells in your prostate gland. A PSA test measures PSA levels in blood, and normal results should be under 4.0 ng/mL. PSA levels above this threshold should be investigated because it may indicate prostate cancer, although other factors that might increase PSA levels include: an enlarged For men aged 70 to 79, they suggested a normal serum PSA reference range of 0.0-6.5 ng/mL (0.0-6.5 μg/L). In our population, 38% of patients with clinically significant and 37% with high-grade prostate cancer had a serum PSA level lower than 6.5 μg/L and would have been missed using age-specific guidelines. PSA results: Normal levels usually range from 0 to 4 μg/L, although age-specific values (upper limit of normal) are frequently reported as follows: 40 - 49 years 2.5 μg/L 50 - 59 years 3.5 μg/L 60 - 69 years 4.5 μg/L 70 - 79 years 6.5 μg/L PSA results between 4 and 10 μg/L are considered mildly A prostate-specific antigen (PSA) test. Urgent referral should be considered if a person's PSA level is above the threshold for their age (for example, more than 4.5 in a person aged 60-69 years). The person's preferences and any comorbidities should be taken into consideration when making the decision. Repeated age related PSA is Repeated age related PSA is raised within the normal range Treat symptoms Consider repeating PSA at 6 months to ensure stability Raised age related PSA and non-suspicious DRE Under 50 years of age ≥2µg/L 50-59 ≥3˛g/L 60-69 ≥4˛g/L 70+ ≥5˛g/L The PSA density (PSAD), is a calculation performed at diagnosis and is the serum prostate specific antigen (PSA) level (ng/mL) divided by the volume of the prostate gland (mL), resulting in a value with the units, ng/mL 2 1.Prostate volume is calculated from TRUS measurements 2,3.. Alternatively, PSA density may be calculated using MRI measurements of prostate volumes or less commonly, using .
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